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- 000 03466nam a2200337 i 4500
- 008 160125s2016 sz a b 001 0 eng d
- 020 __ |a 9783319270142 (hbk.)
- 020 __ |a 9783319270166 (ebk.)
- 040 __ |a UtOrBLW |b eng |c UtOrBLW |e rda |d UtOrBLW
- 099 __ |a CAL 022016055539
- 245 00 |a Management of chemotherapy-induced nausea and vomiting : |b new agents and new uses of current agents / |c edited by Rudolph M. Navari.
- 264 _1 |a Cham : |b Springer, |c 2016.
- 300 __ |a viii, 181 pages : |b illustrations ; |c 24 cm.
- 336 __ |a text |b txt |2 rdacontent.
- 337 __ |a unmediated |b n |2 rdamedia.
- 338 __ |a volume |b nc |2 rdacarrier.
- 504 __ |a Includes bibliographical references and index.
- 505 0_ |a 1. Introduction -- 2. The Physiology and Pharmacology of Nausea and Vomiting Induced by Anti-Cancer Chemotherapy in Humans -- 3. First Generation 5HT-3 Receptor Antagonists -- 4. Second Generation Serotonin (5-HT3) Receptor Antagonist Palonosetron -- 5. The Role of Neurokinin-1 Receptor Antagonists in CINV -- 6. Olanzapine for the prevention of Chemotherapy-Induced Nausea and Vomiting -- 7. Gabapentin for the Prevention of CINV -- 8. Prevention of CINV in Patients Receiving High-Dose Multiple-Day Chemotherapy -- 9. Clinical Management of CINV -- 10. Treatment of Chemotherapy-Induced Nausea -- 11. Conclusions -- 12. Future Directions.
- 520 __ |a This book provides a comprehensive review of new agents, a detailed description of new uses of current agents, and an integration of the available agents in clinical practice. A description of a detailed clinical approach provides clinical practitioners with the most up-to-date recommendations for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in various clinical settings. CINV is one of the most feared treatment related toxicities. Patient surveys for the past thirty years consistently demonstrate patients perception of deterioration in quality of life due to chemotherapy treatments. The introduction of the antiemetics, serotonin 5-HT3 receptor antagonists and the neurokinin-1 receptor antagonists, have improved the control of chemotherapy-induced emesis, but the treatment of chemotherapy-induced nausea remains a significant clinical problem. Patients continue to have quality of life issues which prevent normal functioning during active treatment. New agents such as the second generation 5-HT3 receptor antagonist palonosetron and the new neuroknin-1 receptor antagonists rolapitant and netupitant are being introduced into clinical practice, and it is anticipated that these new agents will improve the control of CINV. Agents such as olanzapine (a FDA approved anti-psychotic), gabapentin (a FDA approved neuroleptic), and ginger (a food additive), which have been used primarily for other indications, are now being tested as potential, effective antiemetics. This work represents the first available comprehensive summary that details all new antiemetic agents and, particularly, their clinical role in treating patients; an important reference for practitioners seeking to improve the quality of life of patients undergoing chemotherapy.
- 700 1_ |a Navari, Rudolph M., |e editor.
- 950 __ |a JHUL |b R96 |c M266