MARC状态：审校 文献类型：西文图书 浏览次数：73
- 题名/责任者:
- CPP, cell-penetrating peptides / Ulo Langel.
- 出版发行项:
- Singapore : Springer, [2019]
- ISBN:
- 9789811387463
- ISBN:
- 981138746X
- 载体形态项:
- xii, 470 pages : illustrations (some color) ; 24 cm
- 个人责任者:
- Langel, Ulo, author.
- 论题主题:
- Peptides.
- 论题主题:
- Biochemistry.
- 论题主题:
- Medicine.
- 论题主题:
- Cell-Penetrating Peptides-pharmacokinetics.
- 论题主题:
- Cell-Penetrating Peptides-therapeutic use.
- 论题主题:
- Drug Carriers.
- 中图法分类号:
- Q516
- 书目附注:
- Includes bibliographical references and index.
- 内容附注:
- Classes and applications of CPP -- CPP functionalization -- Protein delivery and mimicry -- Targeting strategies -- Methods for detection and visualization of CPPs -- Methods for structural studies of CPPs -- Kinetics -- Toxicity and immune response -- Cell-translocation mechanisms of CPPs -- Clinical trials and commercialization using CPPs -- Therapeutic potential of CPPs.
- 摘要附注:
- In this book, a summary and update of the most important areas of CPP research are presented, whilst raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo are discussed. Therapeutic potential of CPPs and commercial developments are discussed. The monograph is written for researchers and students in the field.
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