- 题名/责任者:
- Collagen biografts for tunable drug delivery / Rucha Joshi.
- 出版发行项:
- Cham, Switzerland : Springer, [2021]
- ISBN:
- 9783030638160 :
- 载体形态项:
- xii, 107 pages : illustrations ; 24 cm.
- 个人责任者:
- Joshi, Rucha (Rucha Vinay), author.
- 论题主题:
- Biomedical materials-Therapeutic use.
- 论题主题:
- Collagen-Therapeutic use.
- 论题主题:
- Drugs-Controlled release.
- 论题主题:
- Tissue engineering.
- 论题主题:
- Biomedical engineering.
- 中图法分类号:
- R318.08
- 书目附注:
- Includes bibliographical references and index.
- 内容附注:
- Introduction to drug delivery -- From in vivo synthesis to in vitro drug delivery device formation -- Creating tunable collagen matrices : an approach inspired by in-vivo collagen synthesis and self-assembly -- Collagen biografts for chronic wound healing -- Application of collagen fibril biografts for enhancing local vascularization in an in-vivo chick chorioallantoic membrane (CAM) model.
- 摘要附注:
- This book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen ; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery.
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