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Online Public Access Catalogue

题名/责任者:

Stress and mental disorders : insights from animal models / Richard McCarty.

出版发行项:

New York, NY : Oxford University Press, 2020.

ISBN:

9780190697266

ISBN:

0190697261

载体形态项:

xi, 656 pages, 8 unnumbered pages of color plates : illustrations ; 26 cm

变异题名:

Insights from animal models

个人责任者:

McCarty, Richard, 1947- author.

论题主题:

Stress (Physiology)

论题主题:

Stress (Psychology)

论题主题:

Neuroendocrinology.

中图法分类号:

B845

书目附注:

Includes bibliographical references and index.

内容附注:

Introduction -- 1. Psychiatric Illnesses: An Overview -- 2. Making the Case: Stress and Mental Disorders -- 3. Evolution of the Stress Concept -- 4. Stress Effector Systems -- 5. Stress-Sensitive Brain Circuits -- 6. Animal Models in Psychiatry -- 7. Stress, Development, and Epigenetics -- 8. Stress and Schizophrenia -- 9. Stress and Autism Spectrum Disorder -- 10. Stress and Bipolar Disorder -- 11. Stress and Anxiety Disorders -- 12. Stress and Depression: Part 1 -- 13. Stress and Depression: Part 2 -- 14. Post-Traumatic Stress Disorder -- 15. Resilience -- 16. Thoughts for the Future -- References -- Index.

摘要附注:

"Stress has now been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. This book begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioural alterations as a newer approach to understand why some animals (e.g. inbred mice) are susceptible to stress and others are resilient, even if they are essentially genetically identical. The final chapter discusses how these basic laboratory animal models are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders"--

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