MARC状态：审校 文献类型：西文图书 浏览次数：38
- 题名/责任者:
- Boron-base compounds : potential and emerging applications in medicine / edited by Evamarie Hey-Hawkins, Clara Vi?as Teixidor.
- 出版发行项:
- Hoboken, NJ, USA : John Wiley & Sons, Ltd, 2018
- ISBN:
- 9781119275558
- 载体形态项:
- xx, 470 pages : illustrations (some color) ; 25 cm.
- 其他载体形态:
- Print version: Boron-base compounds. First edition. Hoboken, NJ, USA : Wiley, [2018] 9781119275558
- 附加个人名称:
- Hey-Hawkins, Evamarie, 1957- editor
- 附加个人名称:
- Teixidor, Clara Vi?as
- 论题主题:
- Boron compounds.
- 论题主题:
- Boron compounds-Diagnostic use.
- 论题主题:
- Boron compounds-Therapeutic use.
- 中图法分类号:
- R313
- 书目附注:
- Includes bibliographical references and index
- 内容附注:
- List of Contributors vii Preface xi Part 1 Design of New Boron-based Drugs 1 1.1 Carboranes as Hydrophobic Pharmacophores: Applications for Design of Nuclear Receptor Ligands 3; Yasuyuki Endo 1.2 Boron Cluster Modifications with Antiviral, Anticancer, and Modulation of Purinergic Receptors' Activities Based on Nucleoside Structures 20; Anna Adamska-Bart?omiejczyk, Katarzyna Bednarska, Magdalena Bia?ek-Pietras, Zofia M. Kilia艅ska, Adam Mieczkowski, Agnieszka B. Olejniczak, Edyta Paradowska, Miros?awa Studzi艅ska, Zofia Su?owska, Jolanta D. ?o?nierczyk, and Zbigniew J
- 内容附注:
- Lesnikowski 1.3 Design of Carborane-Based Hypoxia-Inducible Factor Inhibitors 35; Guangzhe Li, Hyun Seung Ban, and Hiroyuki Nakamura 1.4 Half- and Mixed-Sandwich Transition Metal Dicarbollides and nido-Carboranes(-1) for Medicinal Applications 60; Benedikt Schwarze, Marta Gozzi, and Evamarie Hey-Hawkins 1.5 Ionic Boron Clusters as Superchaotropic Anions: Implications for Drug Design 109; Khaleel I. Assaf, Joanna Wilinska, and Detlef Gabel 1.6 Quantum Mechanical and Molecular Mechanical Calculations on Substituted Boron Clusters and Their Interactions with Proteins 126; Jind?ich Fanfrl铆k, Adam Pecina, Jan ?ez谩?, Pavel Hobza, and Martin Lep?铆k Part 2 Boron Compounds in Drug Delivery and Imaging 139 2.1 Closomers: An Icosahedral Platform for Drug Delivery 141; Satish S
- 内容附注:
- Jalisatgi 2.2 Cobaltabisdicarbollide-based Synthetic Vesicles: From Biological Interaction to in vivo Imaging 159; Clara Vi?as, Francesc Teixidor, and Adrian J. Harwood 2.3 Boronic Acid-Based Sensor for Determination of Sugars 174; Igor B. Sivaev and Vladimir I. Bregadze 2.4 Boron Compounds in Molecular Imaging 205; Bhaskar C. Das, Devi Prasan Ojha, Sasmita Das, and Todd Evans 2.5 Radiolabeling Strategies for Boron Clusters: Toward Fast Development and Efficient Assessment of BNCT Drug Candidates 232; Kiran B
- 内容附注:
- Gona, Vanessa G贸mez-Vallejo, Irina Manea, Jonas Malmquist, Jacek Koziorowski, and Jordi Llop Part 3 Boron Compounds for Boron Neutron Capture Therapy 269 3.1 Twenty Years of Research on 3-Carboranyl Thymidine Analogs (3CTAs): A Critical Perspective 271; Werner Tjarks 3.2 Recent Advances in Boron Delivery Agents for Boron Neutron Capture Therapy (BNCT) 298; Sunting Xuan and Maria da Gra?a H. Vicente 3.3 Carborane Derivatives of Porphyrins and Chlorins for Photodynamic and Boron Neutron Capture Therapies: Synthetic Strategies 343; Valentina A. Ol'shevskaya, Andrei V. Zaitsev, and Alexander A
- 内容附注:
- Shtil 3.4 Nanostructured Boron Compounds for Boron Neutron Capture Therapy (BNCT) in Cancer Treatment 371; Shanmin Gao, Yinghuai Zhu, and Narayan Hosmane 3.5 New Boronated Compounds for an Imaging-Guided Personalized Neutron Capture Therapy 389; Nicoletta Protti, Annamaria Deagostino, Paolo Boggio, Diego Alberti, and Simonetta Geninatti Crich 3.6 Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies: Research in Animal Models Employing Different Boron Compounds and Administration Strategies 416; Amanda E. Schwint, Andrea Monti Hughes, Marcela A. Garabalino, Emiliano C.C. Pozzi, Elisa M. Heber, and Veronica A. Trivillin Index
- 摘要附注:
- Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics' Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds.' The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: -Contains contributions from a panel of internationally renowned experts in the field -Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics -Highlights the range and capacity of boron-based compounds in medical applications -Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics
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